Association of the Human Lymphocyte-DR2 Antigen with Japanese Ulcerative Colitis

Hitoshi Asakura, Masaharu Tsuchiya, Sadakazu Aiso, Mamoru Watanabe, Kensuke Kobayashi, Toshifumi Hibi, Koshi Ando, Hajime Takata, Susumu Sekiguchi

研究成果: Article

141 引用 (Scopus)

抄録

The frequency deviation of human lymphocyte-DR antigens as well as human lymphocyte A, B, and C antigens was assessed in 40 Japanese patients with ulcerative colitis and compared with 51 ethnically matched healthy Japanese. The antigen that was o f significantly higher frequency in patients with ulcerative colitis was HLA-DR2. This antigen was found in 70% o f the patients vs. 31% of controls (χ2 = 13.4, p < 0.001, corrected p < 0.01, relative risk = 5.1). In addition, an increased frequency o f HLA-B5-DR2, which is the most common haplotype in Japanese populations, was found in 55% of the patients with ulcerative colitis compared with 22% of the controls (χ2 = 10.84, p < 0.001).

元の言語English
ページ(範囲)413-418
ページ数6
ジャーナルGastroenterology
82
発行部数3
DOI
出版物ステータスPublished - 1982 1 1
外部発表Yes

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

これを引用

Asakura, H., Tsuchiya, M., Aiso, S., Watanabe, M., Kobayashi, K., Hibi, T., ... Sekiguchi, S. (1982). Association of the Human Lymphocyte-DR2 Antigen with Japanese Ulcerative Colitis. Gastroenterology, 82(3), 413-418. https://doi.org/10.1016/S0016-5085(82)80387-9

Association of the Human Lymphocyte-DR2 Antigen with Japanese Ulcerative Colitis. / Asakura, Hitoshi; Tsuchiya, Masaharu; Aiso, Sadakazu; Watanabe, Mamoru; Kobayashi, Kensuke; Hibi, Toshifumi; Ando, Koshi; Takata, Hajime; Sekiguchi, Susumu.

:: Gastroenterology, 巻 82, 番号 3, 01.01.1982, p. 413-418.

研究成果: Article

Asakura, H, Tsuchiya, M, Aiso, S, Watanabe, M, Kobayashi, K, Hibi, T, Ando, K, Takata, H & Sekiguchi, S 1982, 'Association of the Human Lymphocyte-DR2 Antigen with Japanese Ulcerative Colitis', Gastroenterology, 巻. 82, 番号 3, pp. 413-418. https://doi.org/10.1016/S0016-5085(82)80387-9
Asakura, Hitoshi ; Tsuchiya, Masaharu ; Aiso, Sadakazu ; Watanabe, Mamoru ; Kobayashi, Kensuke ; Hibi, Toshifumi ; Ando, Koshi ; Takata, Hajime ; Sekiguchi, Susumu. / Association of the Human Lymphocyte-DR2 Antigen with Japanese Ulcerative Colitis. :: Gastroenterology. 1982 ; 巻 82, 番号 3. pp. 413-418.
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abstract = "The frequency deviation of human lymphocyte-DR antigens as well as human lymphocyte A, B, and C antigens was assessed in 40 Japanese patients with ulcerative colitis and compared with 51 ethnically matched healthy Japanese. The antigen that was o f significantly higher frequency in patients with ulcerative colitis was HLA-DR2. This antigen was found in 70{\%} o f the patients vs. 31{\%} of controls (χ2 = 13.4, p < 0.001, corrected p < 0.01, relative risk = 5.1). In addition, an increased frequency o f HLA-B5-DR2, which is the most common haplotype in Japanese populations, was found in 55{\%} of the patients with ulcerative colitis compared with 22{\%} of the controls (χ2 = 10.84, p < 0.001).",
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