The frequency deviation of human lymphocyte-DR antigens as well as human lymphocyte A, B, and C antigens was assessed in 40 Japanese patients with ulcerative colitis and compared with 51 ethnically matched healthy Japanese. The antigen that was o f significantly higher frequency in patients with ulcerative colitis was HLA-DR2. This antigen was found in 70% o f the patients vs. 31% of controls (χ2 = 13.4, p < 0.001, corrected p < 0.01, relative risk = 5.1). In addition, an increased frequency o f HLA-B5-DR2, which is the most common haplotype in Japanese populations, was found in 55% of the patients with ulcerative colitis compared with 22% of the controls (χ2 = 10.84, p < 0.001).
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