Asymmetric Synthesis of Isotopic Atropisomers based on ortho-CH3/CD3Discrimination and Their Structural Properties

Shota Miwa, Ryunosuke Senda, Kazuya Saito, Azusa Sato, Yuko Nakamura, Osamu Kitagawa

研究成果: Review article査読

抄録

N-C axially chiral 3-(2-trideuteriomethyl-4,6-dimethylphenyl)-2-ethylquinazolin-4-ones and 3-(2-trideuteriomethyl-4,6-dimethylphenyl)-2-(1-phenylpropan-2-yl)quinazolin-4-ones were prepared in high enantio- and diastereomeric purities (98% ee). These quinazolinone derivatives are isotopic atropisomers based on ortho-CH3/CD3discrimination and were revealed to possess a slight optical rotation and high rotational stability.

本文言語English
ページ(範囲)13501-13507
ページ数7
ジャーナルJournal of Organic Chemistry
87
21
DOI
出版ステータスPublished - 2022 11月 4

ASJC Scopus subject areas

  • 有機化学

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