Bedside cancer cell collector using size-dependent cell filtration in microfluidic chip

T. Masuda, M. Niimi, H. Nakanishi, Y. Yamanishi, F. Arai

研究成果: Conference contribution

抄録

We have developed the microfluidic chip to isolate gastric cancer cells from the peritoneal washing. Gastric cancer cells, which tend to be agglomerated in the peritoneal washing, are bigger than the other cells and the fragment of soft tissue. In this paper, we present a novel biochip to enrich low-concentrated cancer cells in the peritoneal washing by size-dependent cell filtration. This biochip has an advantage to avoid high-accuracy control of the flow rate because the cancer cells were filtered by the gap of the microchannel. Two-step exposure was carried out to achieve the precise 3D uneven channel for cell filtration. Furthermore by setting fins in the microchannel to assist the sheath flow, the capability to enrich the cancer cells was improved. As a result, we succeeded in double enrichment of the cancer cells in the quasi peritoneal washing.

本文言語English
ホスト出版物のタイトル15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
ページ1215-1217
ページ数3
出版ステータスPublished - 2011 12 1
イベント15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 - Seattle, WA, United States
継続期間: 2011 10 22011 10 6

出版物シリーズ

名前15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
2

Conference

Conference15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
国/地域United States
CitySeattle, WA
Period11/10/211/10/6

ASJC Scopus subject areas

  • 制御およびシステム工学

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