This paper concerns with the prediction and prevention of skeletal muscle injury. To clarify the mechanism of muscle injury, we conducted biomechanical and pathological evaluations for muscle contusion and strain-injury. The results showed correlations between severity of pathological damage and functional disability on contraction. The results also suggested that microscopic damage of muscle fibers, peripheral circulation or motor units has significant effects on the change of macroscopic function, and that microscopic examination is prerequisite to understand these phenomena. As a preliminary study, previous papers on microstructural elements of muscle are reviewed.
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