Cardiovascular adaptation in response to chronic hypoxia in awake rats

Saki Hamashima, Masahiro Shibata

研究成果: Conference contribution

3 被引用数 (Scopus)

抄録

To examine how cardiovascular adaptation to chronic hypoxia might evolve, the responses to blood pressure (Pt) and hematocrit (Ht) during long-term systemic exposure to hypoxia were observed in awake rats. Furthermore, the total peripheral vascular resistance (TPR) was estimated using direct measurements of systemic blood pressure (Ps) and blood flow (Qs) in carotid artery based on Darcy’s law (TPR¼Ps/Qs) to evaluate the remodeling procedure in the microcirculation. BP and Ht under normoxic conditions were kept almost constant, while hypoxic exposure immediately increased Ht to 58% and, thereafter, it remained stable. The TPR values showed no significant differences between hypoxic and normoxic conditions. These results suggest that effects of high viscosity caused by increasing Ht on peripheral vascular resistance can be compensated by inducing microvascular remodeling with the arteriolar dilation and capillary angiogenesis.

本文言語English
ホスト出版物のタイトルAdvances in Experimental Medicine and Biology
出版社Springer New York LLC
ページ241-246
ページ数6
876
ISBN(印刷版)9781493930227
DOI
出版ステータスPublished - 2016
イベント42nd Annual Meeting of International Society on Oxygen Transport to Tissue - London, United Kingdom
継続期間: 2014 6 282014 7 3

出版物シリーズ

名前Advances in Experimental Medicine and Biology
876
ISSN(印刷版)00652598
ISSN(電子版)22148019

Other

Other42nd Annual Meeting of International Society on Oxygen Transport to Tissue
国/地域United Kingdom
CityLondon
Period14/6/2814/7/3

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学(全般)
  • 医学(全般)

フィンガープリント

「Cardiovascular adaptation in response to chronic hypoxia in awake rats」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル