抄録
To examine how cardiovascular adaptation to chronic hypoxia might evolve, the responses to blood pressure (Pt) and hematocrit (Ht) during long-term systemic exposure to hypoxia were observed in awake rats. Furthermore, the total peripheral vascular resistance (TPR) was estimated using direct measurements of systemic blood pressure (Ps) and blood flow (Qs) in carotid artery based on Darcy’s law (TPR¼Ps/Qs) to evaluate the remodeling procedure in the microcirculation. BP and Ht under normoxic conditions were kept almost constant, while hypoxic exposure immediately increased Ht to 58% and, thereafter, it remained stable. The TPR values showed no significant differences between hypoxic and normoxic conditions. These results suggest that effects of high viscosity caused by increasing Ht on peripheral vascular resistance can be compensated by inducing microvascular remodeling with the arteriolar dilation and capillary angiogenesis.
| 元の言語 | English |
|---|---|
| ホスト出版物のタイトル | Advances in Experimental Medicine and Biology |
| 出版者 | Springer New York LLC |
| ページ | 241-246 |
| ページ数 | 6 |
| 巻 | 876 |
| ISBN（印刷物） | 9781493930227 |
| DOI | |
| 出版物ステータス | Published - 2016 |
| イベント | 42nd Annual Meeting of International Society on Oxygen Transport to Tissue - London, United Kingdom 継続期間: 2014 6 28 → 2014 7 3 |
出版物シリーズ
| 名前 | Advances in Experimental Medicine and Biology |
|---|---|
| 巻 | 876 |
| ISSN（印刷物） | 00652598 |
| ISSN（電子版） | 22148019 |
Other
| Other | 42nd Annual Meeting of International Society on Oxygen Transport to Tissue |
|---|---|
| 国 | United Kingdom |
| 市 | London |
| 期間 | 14/6/28 → 14/7/3 |
Fingerprint
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Medicine(all)
これを引用
Cardiovascular adaptation in response to chronic hypoxia in awake rats. / Hamashima, Saki; Shibata, Masahiro.
Advances in Experimental Medicine and Biology. 巻 876 Springer New York LLC, 2016. p. 241-246 (Advances in Experimental Medicine and Biology; 巻 876).研究成果: Conference contribution
}
TY - GEN
T1 - Cardiovascular adaptation in response to chronic hypoxia in awake rats
AU - Hamashima, Saki
AU - Shibata, Masahiro
PY - 2016
Y1 - 2016
N2 - To examine how cardiovascular adaptation to chronic hypoxia might evolve, the responses to blood pressure (Pt) and hematocrit (Ht) during long-term systemic exposure to hypoxia were observed in awake rats. Furthermore, the total peripheral vascular resistance (TPR) was estimated using direct measurements of systemic blood pressure (Ps) and blood flow (Qs) in carotid artery based on Darcy’s law (TPR¼Ps/Qs) to evaluate the remodeling procedure in the microcirculation. BP and Ht under normoxic conditions were kept almost constant, while hypoxic exposure immediately increased Ht to 58% and, thereafter, it remained stable. The TPR values showed no significant differences between hypoxic and normoxic conditions. These results suggest that effects of high viscosity caused by increasing Ht on peripheral vascular resistance can be compensated by inducing microvascular remodeling with the arteriolar dilation and capillary angiogenesis.
AB - To examine how cardiovascular adaptation to chronic hypoxia might evolve, the responses to blood pressure (Pt) and hematocrit (Ht) during long-term systemic exposure to hypoxia were observed in awake rats. Furthermore, the total peripheral vascular resistance (TPR) was estimated using direct measurements of systemic blood pressure (Ps) and blood flow (Qs) in carotid artery based on Darcy’s law (TPR¼Ps/Qs) to evaluate the remodeling procedure in the microcirculation. BP and Ht under normoxic conditions were kept almost constant, while hypoxic exposure immediately increased Ht to 58% and, thereafter, it remained stable. The TPR values showed no significant differences between hypoxic and normoxic conditions. These results suggest that effects of high viscosity caused by increasing Ht on peripheral vascular resistance can be compensated by inducing microvascular remodeling with the arteriolar dilation and capillary angiogenesis.
KW - Awake rats
KW - Hypoxia
KW - Microvascular remodeling
KW - Total peripheral vascular resistance
UR - http://www.scopus.com/inward/record.url?scp=84958580507&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84958580507&partnerID=8YFLogxK
U2 - 10.1007/978-1-4939-3023-4_30
DO - 10.1007/978-1-4939-3023-4_30
M3 - Conference contribution
C2 - 26782218
AN - SCOPUS:84958580507
SN - 9781493930227
VL - 876
T3 - Advances in Experimental Medicine and Biology
SP - 241
EP - 246
BT - Advances in Experimental Medicine and Biology
PB - Springer New York LLC
ER -