Catalytic asymmetric synthesis of vicinal diamine derivatives through enantioselective N-allylation using chiral π-allyl Pd-catalyst

Osamu Kitagawa, Kanako Yotsumoto, Mitsuteru Kohriyama, Yasuo Dobashi, Takeo Taguchi

研究成果: Article査読

29 被引用数 (Scopus)

抄録

(Chemical Equation Presented) N-Monoallylation of meso-vicinal diamine bistrisylamides using a chiral π-allyl-Pd catalyst proceeded in an enantioselective manner (up to 90% ee) to give desymmetrization products in good yields. The product was converted to the known σ-receptor agonist in short steps. In addition, the present catalytic asymmetric N-allylation was applied to kinetic resolution of racemic-diamide.

本文言語English
ページ(範囲)3605-3607
ページ数3
ジャーナルOrganic Letters
6
20
DOI
出版ステータスPublished - 2004 9 30
外部発表はい

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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