Catalytic enantioselective synthesis of key intermediates for NET inhibitors using atropisomeric lactam chemistry

Osamu Kitagawa, Daisuke Kurihara, Hajime Tanabe, Taichi Shibuya, Takeo Taguchi

研究成果: Article

27 引用 (Scopus)

抜粋

An atropisomeric lactam which was prepared with high enantioselectivity by catalytic asymmetric intramolecular N-arylation, was efficiently converted to synthetic intermediates for NET inhibitors through highly diastereoselective α-alkylation followed by hydration and trans-tert-butylation.

元の言語English
ページ(範囲)471-474
ページ数4
ジャーナルTetrahedron Letters
49
発行部数3
DOI
出版物ステータスPublished - 2008 1 14
外部発表Yes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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