Catalytic Enantioselective Synthesis of N-C Axially Chiral Phenanthridin-6-one Derivatives

Tomoaki Hirata, Isao Takahashi, Yuya Suzuki, Hiroaki Yoshida, Hiroshi Hasegawa, Osamu Kitagawa

研究成果: Article

21 引用 (Scopus)

抜粋

N-C axially chiral phenanthridin-6-one derivatives bearing various ortho-substituted phenyl groups on the nitrogen atom were enantioselectively prepared through (R)-DTBM-SEGPHOS-Pd(OAc)2-catalyzed intramolecular Buchwald-Hartwig amination. The enantioselectivity strongly depended on solvents, bases, and reaction temperature as well as on the bulkiness of ortho-substituents.

元の言語English
ページ(範囲)318-323
ページ数6
ジャーナルJournal of Organic Chemistry
81
発行部数1
DOI
出版物ステータスPublished - 2016 1 4

ASJC Scopus subject areas

  • Organic Chemistry

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