Catalytic Enantioselective Synthesis of N-C Axially Chiral Phenanthridin-6-one Derivatives

Tomoaki Hirata, Isao Takahashi, Yuya Suzuki, Hiroaki Yoshida, Hiroshi Hasegawa, Osamu Kitagawa

研究成果: Article

15 引用 (Scopus)

抄録

N-C axially chiral phenanthridin-6-one derivatives bearing various ortho-substituted phenyl groups on the nitrogen atom were enantioselectively prepared through (R)-DTBM-SEGPHOS-Pd(OAc)2-catalyzed intramolecular Buchwald-Hartwig amination. The enantioselectivity strongly depended on solvents, bases, and reaction temperature as well as on the bulkiness of ortho-substituents.

元の言語English
ページ(範囲)318-323
ページ数6
ジャーナルJournal of Organic Chemistry
81
発行部数1
DOI
出版物ステータスPublished - 2016 1 4

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Bearings (structural)
Amination
Enantioselectivity
Nitrogen
Derivatives
Atoms
Temperature
palladium(II) acetate

ASJC Scopus subject areas

  • Organic Chemistry

これを引用

Catalytic Enantioselective Synthesis of N-C Axially Chiral Phenanthridin-6-one Derivatives. / Hirata, Tomoaki; Takahashi, Isao; Suzuki, Yuya; Yoshida, Hiroaki; Hasegawa, Hiroshi; Kitagawa, Osamu.

:: Journal of Organic Chemistry, 巻 81, 番号 1, 04.01.2016, p. 318-323.

研究成果: Article

Hirata, Tomoaki ; Takahashi, Isao ; Suzuki, Yuya ; Yoshida, Hiroaki ; Hasegawa, Hiroshi ; Kitagawa, Osamu. / Catalytic Enantioselective Synthesis of N-C Axially Chiral Phenanthridin-6-one Derivatives. :: Journal of Organic Chemistry. 2016 ; 巻 81, 番号 1. pp. 318-323.
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