Characterization of a novel member of the FGFR family, HrFGFR, in Halocynthia roretzi

Shuichi Kamei, Ichiro Yajima, Hiroaki Yamamoto, Ako Kobayashi, Kazuhiro W. Makabe, Hidetoshi Yamazaki, Shin Ichi Hayashi, Takahiro Kunisada

研究成果: Article査読

16 被引用数 (Scopus)


The cDNA for a novel member of the FGFR family, named HrFGFR, was isolated from a Halocynthia roretzi cDNA library prepared at the mid-tailbud stage. This cDNA was 3507b long, and the deduced amino acid sequence contained a motif characteristic of the vertebrate FGFRs. The existence of a single copy of the FGFR homologue gene in H. roretzi was suggested by restriction site analysis of multiple clones. HrFGFR mRNA was expressed strongly in the posterior region in the epidermis from the middle neurula stage. By contrast, Xenopus FGFR homologues are expressed in the anterior region and are known to induce anterior neural formation. A transition of the region expressing FGFR might have induced the more complicated brain or head formation characteristic of vertebrates. (C) 2000 Academic Press.

ジャーナルBiochemical and Biophysical Research Communications
出版ステータスPublished - 2000 8月 28

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学


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