Chiral additive induced self-disproportionation of enantiomers under MPLC conditions: Preparation of enantiomerically pure samples of 1-(aryl)ethylamines from racemates

Mitsuhiro Goto, Kaori Tateishi, Kenki Ebine, Vadim A. Soloshonok, Christian Roussel, Osamu Kitagawa

研究成果: Article査読

12 被引用数 (Scopus)

抄録

Mixtures of enantiomerically pure (S)-N-formyl-1-phenylethyamine and various racemic N-formyl-1-arylethylamine derivatives, when submitted to achiral medium pressure liquid chromatography, afforded elution profiles in which the enantiomers of N-formyl-1-arylethylamines standout as separate peaks and can be isolated. In all of the investigated N-formyl-1-arylethylamine substrates, the virtually enantiomerically pure (S)-enantiomer eluted as a less polar fraction and subsequently, the (R)-enriched enantiomer mixtures were eluted in the more polar fractions.

本文言語English
ページ(範囲)317-321
ページ数5
ジャーナルTetrahedron Asymmetry
27
7-8
DOI
出版ステータスPublished - 2016 5 1

ASJC Scopus subject areas

  • 触媒
  • 物理化学および理論化学
  • 有機化学
  • 無機化学

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