Construction of DNA-Au nanoparticles multilayer and its application to detection of DNA hybridization

Hongchun Liu, Akira Yamaguchi, Masayuki Hayashida, Shigeki Matsuo, Hiroaki Misawa

研究成果: Article査読

5 被引用数 (Scopus)

抄録

We have developed a sensitive detection system for DNA hybridization containing DNA-Au nanoparticles (DNA-GPs) multilayer which leads to the enhancement of the detection sensitivity of surface plasmon resonance (SPR) signals. The SPR angular shift, which is the difference in the SPR angles before and after hybridization, becomes amplified with increasing number of layers of the DNA-GPs. A similar increase in SPR angular shift was obtained for the target DNA with low concentration. The reason for the enhancement is attributed to the interaction between Au nanoparticles and the Au film, as well as the increase in immobilized probe DNA content on the substrate.

本文言語English
ページ(範囲)2767-2770
ページ数4
ジャーナルJapanese Journal of Applied Physics, Part 1: Regular Papers and Short Notes and Review Papers
43
5 A
DOI
出版ステータスPublished - 2004 5
外部発表はい

ASJC Scopus subject areas

  • 工学(全般)
  • 物理学および天文学(全般)

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