Correlation of within-individual fluctuation of depressed mood with prefrontal cortex activity during verbal working memory task: Optical topography study

Hiroki Sato, Ryuta Aoki, Takusige Katura, Ryoichi Matsuda, Hideaki Koizumi

研究成果: Article

31 引用 (Scopus)

抜粋

Previous studies showed that interindividual variations in mood state are associated with prefrontal cortex (PFC) activity. In this study, we focused on the depressed-mood state under natural circumstances and examined the relationship between within-individual changes over time in this mood state and PFC activity.We used optical topography (OT), a functional imaging technique based on near-infrared spectroscopy, to measure PFC activity for each participant in three experimental sessions repeated at 2-week intervals. In each session, the participants completed a self-report questionnaire of mood state and underwent OT measurement while performing verbal and spatial working memory (WM) tasks. The results showed that changes in the depressed-mood score between successive sessions were negatively correlated with those in the left PFC activation for the verbal WM task (P = -0.56, p < 0.05). In contrast, the PFC activation for the spatial WM task did not co-vary with participants' mood changes. We thus demonstrated that PFC activity during a verbal WM task varies depending on the participant's depressed mood state, independent of trait factors. This suggests that using optical topography to measure PFC activity during a verbalWM task can be used as a potential state marker for an individual's depressed mood state.

元の言語English
記事番号126007
ジャーナルJournal of biomedical optics
16
発行部数12
DOI
出版物ステータスPublished - 2011 12 1
外部発表Yes

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering

フィンガープリント Correlation of within-individual fluctuation of depressed mood with prefrontal cortex activity during verbal working memory task: Optical topography study' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用