Deletion mapping on chromosome 1p in well-differentiated gastric cancer

T. Ezaki, A. Yanagisawa, K. Ohta, S. Aiso, M. Watanabe, T. Hibi, Y. Kato, T. Nakajima, T. Ariyama, J. Inazawa, Y. Nakamura, A. Horii

研究成果: Article査読

49 被引用数 (Scopus)

抄録

To define the region on the short arm of chromosome 1 that is thought to include one or more tumour-suppressor genes for gastric cancers, we carried out loss of heterozygosity (LOH) studies in 26 gastric adenocarcinomas, using three restriction fragment length polymorphism (RFLP) markers and nine microsatellite markers. All tumours were informative with at least one locus; three revealed replication errors (RERs) at multiple microsatellite loci, and interstitial or telomeric allelic deletions were observed in 12 cases. Deletion mapping of these tumours defined a commonly deleted region between two loci, D1S201 and D1S197, that are 13 cM apart. As two loci within the commonly deleted region, D1S57 (pYNZ2) and D1S62 (pTHI54), were mapped respectively to 1p35 and 1p34.3 by fluorescence in situ hybridisation, we conclude that a locus likely to contain a tumour-suppressor gene for gastric cancer is located within a 13 cM region encompassing these two chromosomal bands.

本文言語English
ページ(範囲)424-428
ページ数5
ジャーナルBritish Journal of Cancer
73
4
DOI
出版ステータスPublished - 1996
外部発表はい

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

フィンガープリント

「Deletion mapping on chromosome 1p in well-differentiated gastric cancer」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル