Design and synthesis of biologically active analogues of vitamin K2: Evaluation of their biological activities with cultured human cell lines

Yoshitomo Suhara; Yoshihisa Hirota; Kimie Nakagawa; Maya Kamao; Naoko Tsugawa; Toshio Okano

doi:10.1016/j.bmc.2007.12.025

Design and synthesis of biologically active analogues of vitamin K₂: Evaluation of their biological activities with cultured human cell lines

Yoshitomo Suhara, Yoshihisa Hirota, Kimie Nakagawa, Maya Kamao, Naoko Tsugawa, Toshio Okano

研究成果: Article › 査読

13 被引用数 (Scopus)

抄録

Novel ω-oxygenated vitamin K₂ analogues were efficiently synthesized and their biological activities were evaluated. Some were biologically active and the side-chain played an important role in γ-carboxylation and apoptosis-inducing activity. The results provide useful information on the structure-activity relationship of vitamin K₂ analogues for the development of new drugs.

本文言語	English
ページ（範囲）	3108-3117
ページ数	10
ジャーナル	Bioorganic and Medicinal Chemistry
巻	16
号	6
DOI	https://doi.org/10.1016/j.bmc.2007.12.025
出版ステータス	Published - 2008 3月 15
外部発表	はい

ASJC Scopus subject areas

生化学
分子医療
分子生物学
薬科学
創薬
臨床生化学
有機化学

文献へのアクセス

10.1016/j.bmc.2007.12.025

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引用スタイル

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AU - Okano, Toshio

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