Novel ω-oxygenated vitamin K2 analogues were efficiently synthesized and their biological activities were evaluated. Some were biologically active and the side-chain played an important role in γ-carboxylation and apoptosis-inducing activity. The results provide useful information on the structure-activity relationship of vitamin K2 analogues for the development of new drugs.
|ジャーナル||Bioorganic and Medicinal Chemistry|
|出版ステータス||Published - 2008 3月 15|
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