Design and synthesis of biologically active analogues of vitamin K2: Evaluation of their biological activities with cultured human cell lines

Yoshitomo Suhara, Yoshihisa Hirota, Kimie Nakagawa, Maya Kamao, Naoko Tsugawa, Toshio Okano

研究成果: Article査読

13 被引用数 (Scopus)

抄録

Novel ω-oxygenated vitamin K2 analogues were efficiently synthesized and their biological activities were evaluated. Some were biologically active and the side-chain played an important role in γ-carboxylation and apoptosis-inducing activity. The results provide useful information on the structure-activity relationship of vitamin K2 analogues for the development of new drugs.

本文言語English
ページ(範囲)3108-3117
ページ数10
ジャーナルBioorganic and Medicinal Chemistry
16
6
DOI
出版ステータスPublished - 2008 3 15
外部発表はい

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

フィンガープリント 「Design and synthesis of biologically active analogues of vitamin K<sub>2</sub>: Evaluation of their biological activities with cultured human cell lines」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル