Development of "brain-on-chip" devise including micropump for rapid administration of transmitters by and voltage imaging system for neurosignal detection

K. Harada, Y. Yoshimi

研究成果: Conference contribution

抄録

We developed a microchip for kinetic analysis of neural response toward chemical stimulation by using rapid electrochemical micropump and realtime voltage imaging. Aplysia neurons stained with a voltage sensitive dye was stimulated by a solution of potassium chloride or acetylcholine administrated by the diaphragm micropump powered by electrolysis. The change in the membrane potential of the neuron was monitored by a fluorescent microscope. The neural response time to acetylcholine was twice as long as that to potassium chloride. The device may be useful for observation of the kinetic effect of therapeutic drugs on neural response to transmitters.

本文言語English
ホスト出版物のタイトル20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
出版社Chemical and Biological Microsystems Society
ページ605-606
ページ数2
ISBN(電子版)9780979806490
出版ステータスPublished - 2016
イベント20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 - Dublin, Ireland
継続期間: 2016 10 92016 10 13

出版物シリーズ

名前20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016

Other

Other20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
CountryIreland
CityDublin
Period16/10/916/10/13

ASJC Scopus subject areas

  • Control and Systems Engineering

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