Diastereoselective iodocarbocyclization of 4-pentenylmalonate derivatives: Application to cyclosarkomycin synthesis

Osamu Kitagawa, Tadashi Inoue, Takeo Taguchi

研究成果: Article査読

25 被引用数 (Scopus)

抄録

The iodocarbocyclization of 4-pentenylmalonate 1 having a substituent at the 2 or 3 position effectively proceeded by treating 1 with I2 and Ti(OtBu)4 in the presence of CuO. Stereoelectronic effect of the subtituent at allylic position on diastereoselectivity was notable. As an application of the present reaction, the efficient synthesis of cyclosarkomycin 7 was achieved.

本文言語English
ページ(範囲)1059-1062
ページ数4
ジャーナルTetrahedron Letters
35
7
DOI
出版ステータスPublished - 1994 2 14
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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