Diastereoselective iodocarbocyclization of 4-pentenylmalonate derivatives: Application to cyclosarkomycin synthesis

Osamu Kitagawa, Tadashi Inoue, Takeo Taguchi

研究成果: Article

24 引用 (Scopus)

抜粋

The iodocarbocyclization of 4-pentenylmalonate 1 having a substituent at the 2 or 3 position effectively proceeded by treating 1 with I2 and Ti(OtBu)4 in the presence of CuO. Stereoelectronic effect of the subtituent at allylic position on diastereoselectivity was notable. As an application of the present reaction, the efficient synthesis of cyclosarkomycin 7 was achieved.

元の言語English
ページ(範囲)1059-1062
ページ数4
ジャーナルTetrahedron Letters
35
発行部数7
DOI
出版物ステータスPublished - 1994 2 14

    フィンガープリント

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

これを引用