Direct correlation between complex conformation and chiral discrimination upon inclusion of amino acid derivatives by β- and γ-cyclodextrins

Guy Hembury, Mikhail Rekharsky, Asao Nakamura, Yoshihisa Inoue

研究成果: Article査読

38 被引用数 (Scopus)

抄録

(matrix presented) A correlation between the conformation and chiral recognition characteristics of a series of modified amino acid complexes with β- and γ-cyclodextrins has been determined, using titration microcalorimetry and 1H NMR techniques. The enantiomeric discrimination (D or L) is found to be dependent on the adoption of one of two distinct conformations. With the magnitude of the chiral discrimination (KD/KL) arising from the guest's depth of penetration into the host's cavity.

本文言語English
ページ(範囲)3257-3260
ページ数4
ジャーナルOrganic Letters
2
21
DOI
出版ステータスPublished - 2000 10月 19
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 物理化学および理論化学
  • 有機化学

フィンガープリント

「Direct correlation between complex conformation and chiral discrimination upon inclusion of amino acid derivatives by β- and γ-cyclodextrins」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル