Dose-response study of daily cocoa intake on the oxidative susceptibility of low-density lipoprotein in healthy human volunteers

Naomi Osakabe, Seigo Baba, Akiko Yasuda, Tamami Iwamoto, Masumi Kamiyama, Takahisa Tokunaga, Kazuo Kondo

研究成果: Article査読

20 被引用数 (Scopus)

抄録

A four-period crossover study was conducted to evaluate the dose-related response of daily cocoa intake on the oxidative susceptibility of low-density lipoprotein (LDL) in healthy human volunteers. Each supplementation phase consisted of a 14-day feeding period followed by a 28-day washout period. During the period, healthy male volunteers (n = 8) ingested 18, 24 or 36 g of cocoa powder per day (1.3, 1.74 or 2.61 g of polyphenols per day). During the control period, these subjects ingested sugar. LDL oxidative susceptibility was measured as the lag time of conjugated diene formation that started with the addition of a radical initiator, 2,2′-azobis (4-methoxy-2,4-dimethyl-valeronitrile). Samples were analyzed at pre-, one week, and two weeks post-supplementation. In the 24 and 36 g cocoa powder ingestion period, significant lag time prolongation was observed. We conclude that the ingestion of more than 24 g of cocoa powder per day (1.74 g of polyphenols) clearly protects LDL from oxidation.

本文言語English
ページ(範囲)679-684
ページ数6
ジャーナルJournal of Health Science
50
6
DOI
出版ステータスPublished - 2004 12月 1
外部発表はい

ASJC Scopus subject areas

  • 毒物学
  • 健康、毒物学および変異誘発

フィンガープリント

「Dose-response study of daily cocoa intake on the oxidative susceptibility of low-density lipoprotein in healthy human volunteers」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル