Effect of angiotensin II on the proliferation of mammotrophs from the adult rat anterior pituitary in culture

Tadashi Shinkai, Hiroshi Ooka

研究成果: Article査読

21 被引用数 (Scopus)

抄録

We measured the influence of prolactin-releasing neuropeptides on mammotroph proliferation in cultures of rat adenohypophysis cells using flow cytometry. Angiotensin II (AII) increased mammotroph proliferation. Other peptides with hormone-releasing activities did not promote growth. Tamoxifen inhibited mammotroph proliferation in control and AII-containing cultures and the inhibition was reversed with β-estradiol. Saralasin, an AII receptor antagonist, suppressed not only AII-induced mammotroph proliferation but also luteinizing hormone-releasing hormone (LHRH)-induced proliferation. These results suggest that hypothalamic LHRH stimulates AII release from gonadotrophs and that AII, with estrogen, controls mammotroph proliferation in rat pituitary.

本文言語English
ページ(範囲)25-29
ページ数5
ジャーナルPeptides
16
1
DOI
出版ステータスPublished - 1995

ASJC Scopus subject areas

  • 生化学
  • 生理学
  • 内分泌学
  • 細胞および分子神経科学

フィンガープリント

「Effect of angiotensin II on the proliferation of mammotrophs from the adult rat anterior pituitary in culture」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル