Effects of polyphenol substances derived from theobroma cacao on gastric mucosal lesion induced by ethanol

Naomi Osakabe, Chiaki Sanbongi, Megumi Yamagishi, Toshio Takizawa, Toshihiko Osawa

研究成果: Article査読

52 被引用数 (Scopus)

抄録

The antiulcer activity of cacao liquor water-soluble crude polyphenols (CWSP) was examined. CWSP, α-tocopherol, sucralfate (500 mg/kg), and cimetidine (250 mg/kg) were orally administerted to male SD rats 30 minutes before ethanol treatment. 5 ml/kg of ethanol given intragastrically caused lesions in mucosa of the glandular stomach. CWSP caused a reduction of such hemorrhagic lesions as well as cimetidine and sucralfate which are typical antiulcer drugs, but α-tocopherol was less effective. Thiobarbituric acid reactive substances in gastric mucosa significantly increased with ethanol administration. CWSP treatment significantly reduced this change. The administration of ethanol extensively increased myeloperoxidase (MPO) but not xanthine oxidase (XOD) activity. CWSP reduced the activities of both enzymes; they were considered the main sources of oxygen radicals. According to an in vitro study, CWSP directly reducted XOD but not MPO. These results suggest that the antiulcer mechanism of CWSP was not only radical scavenging but also modulation of leukocyte function.

本文言語English
ページ(範囲)1535-1538
ページ数4
ジャーナルBioscience, Biotechnology and Biochemistry
62
8
DOI
出版ステータスPublished - 1998
外部発表はい

ASJC Scopus subject areas

  • バイオテクノロジー
  • 分析化学
  • 生化学
  • 応用微生物学とバイオテクノロジー
  • 分子生物学
  • 有機化学

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