Efficient synthesis and biological evaluation of ω-oxygenated analogues of vitamin K2: Study of modification and structure-activity relationship of vitamin K2 metabolites

Yoshitomo Suhara, Aya Murakami, Maya Kamao, Shino Mimatsu, Kimie Nakagawa, Naoko Tsugawa, Toshio Okano

研究成果: Article査読

8 被引用数 (Scopus)

抄録

Novel ω-oxygenated vitamin K2 analogues, which are candidates for metabolites of vitamin K2 homologues, were efficiently synthesized and their apoptosis-inducing activity was evaluated. We revealed that some of those analogues were biologically active and the side-chain part played an important role in apoptosis-inducing activity. Our results can provide useful information to develop the structure-activity relationship of vitamin K2 analogues for new drugs based on vitamin K.

本文言語English
ページ(範囲)1622-1625
ページ数4
ジャーナルBioorganic and Medicinal Chemistry Letters
17
6
DOI
出版ステータスPublished - 2007 3月 15
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 分子医療
  • 分子生物学
  • 薬科学
  • 創薬
  • 臨床生化学
  • 有機化学

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