Efficient synthesis of various atropisomeric amides in optically pure forms and their application to asymmetric reactions

Osamu Kitagawa, Shu ichi Momose, Yoshihisa Fushimi, Takeo Taguchi

研究成果: Article査読

51 被引用数 (Scopus)

抄録

Various atropisomeric amides were prepared in optically pure forms (≥98% ee) through the optical resolution of the amide ester derived from (R)-pantolactone, N-allyl-ortho-tert-butylaniline and oxalyl chloride. Asymmetric carbonyl addition reaction of an alkyllithium and asymmetric iodolactonization with these atropisomeric amides proceeded with high stereoselectivity.

本文言語English
ページ(範囲)8827-8831
ページ数5
ジャーナルTetrahedron Letters
40
50
DOI
出版ステータスPublished - 1999 12 10
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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