Elucidation of the mechanism producing menaquinone-4 in osteoblastic cells

Yoshitomo Suhara, Akimori Wada, Toshio Okano

研究成果: Article

18 引用 (Scopus)

抄録

Vitamin K is an essential nutrient and a cofactor for the carboxylation of specific glutamyl residues of proteins to γ-glutamyl residues, which activates osteocalcin related to bone formation. Among vitamin K homologues, menaquinone-4 (MK-4) is the most active biologically, up-regulating the gene expression of bone markers, and thus has been clinically used in the treatment of osteoporosis in Japan. Recently, we confirmed that MK-4 was converted from dietary phylloquinone (PK), and then accumulated in various tissues at high concentrations. This system should play an important role in biological functions including bone formation, however, the pathway by which MK-4 is converted remains unclear. In this study, we studied the mechanism of MK-4's conversion with chemical techniques using deuterated analogues.

元の言語English
ページ(範囲)1054-1057
ページ数4
ジャーナルBioorganic and Medicinal Chemistry Letters
19
発行部数4
DOI
出版物ステータスPublished - 2009 2 15
外部発表Yes

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Bone
Vitamin K
Carboxylation
Vitamin K 1
Osteocalcin
Gene expression
Nutrients
Tissue
menatetrenone
Proteins

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry

これを引用

Elucidation of the mechanism producing menaquinone-4 in osteoblastic cells. / Suhara, Yoshitomo; Wada, Akimori; Okano, Toshio.

:: Bioorganic and Medicinal Chemistry Letters, 巻 19, 番号 4, 15.02.2009, p. 1054-1057.

研究成果: Article

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