Evaluation of arthritis with model rats using photoacoustic imaging system

Kohei Ogawa, Takeshi Namita, Kengo Kondo, Makoto Yamakawa, Tsuyoshi Shiina

研究成果: Conference contribution

抄録

Associated with local articular rigidity, swelling and pain as well as systemic development of fever and a sense of fatigue, arthritis is a disorder causing deterioration of patients’ quality of life. Approximately 300,000 patients report rheumatoid arthritis, one of the typical chronic joint inflammation, in Japan alone: 1% of the world’s population has the disorder worldwide. Although X-ray CT, MRI, and ultrasonic Doppler method are used for examination and diagnosis, various problems exist such as radiation exposure, administration of contrast agents and difficulty in earlier diagnosis and quantitative evaluation. To resolve these difficulties, we developed a handheld photoacoustic imaging system. In this study, the feasibility of evaluating the degree of inflammation using photoacoustic imaging with multiple wavelengths was investigated with in vivo measurements of model rats. The changes in signal intensity depending on the presence or absence of the disorder was examined. It was confirmed that the signal intensity can be intensified at diseased joints. Then, the changes with different time elapsed from drug administration was examined using rats. It was clarified that the degree of inflammation can be evaluated by shapes of photoacoustic spectra, which changed along with the progress of the inflammation. Through these analyses, we verified the usefulness of photoacoustic imaging for the diagnosis and evaluation of arthritis.

本文言語English
ホスト出版物のタイトルEuropean Conference on Biomedical Optics, ECBO_2019
出版社OSA - The Optical Society
ISBN(電子版)9781557528209
DOI
出版ステータスPublished - 2019
外部発表はい
イベントEuropean Conference on Biomedical Optics, ECBO_2019 - Munich, Netherlands
継続期間: 2019 6月 232019 6月 25

出版物シリーズ

名前Optics InfoBase Conference Papers
Part F142-ECBO 2019

Conference

ConferenceEuropean Conference on Biomedical Optics, ECBO_2019
国/地域Netherlands
CityMunich
Period19/6/2319/6/25

ASJC Scopus subject areas

  • 電子材料、光学材料、および磁性材料
  • 材料力学

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