Evaluation of Pulsatile and Nonpulsatile Flow in Microvessels of the Bulbar Conjunctiva in the Goat with an Undulation Pump Artificial Heart

Atsushi Baba, Petr Dobsak, Shuichi Mochizuki, Itsuro Saito, Takashi Isoyama, Koki Takiura, Masahiro Shibata, Yusuke Abe, Tsuneo Chinzei, Jaromir Vasku, Kou Imachi

研究成果: Article

30 引用 (Scopus)

抄録

This study has three purposes, as follows. The first is to develop a microscopic system to observe the microcirculation of animals implanted with an artificial heart. The second is to investigate the influence of flow pattern change from pulsatile to nonpulsatile on the microcirculation. The third is to study the effects of pulsatility in blood flow on endothelium-derived nitric oxide release in the microvasculature. When the flow pattern was changed from pulsatile to nonpulsatile, the velocity of erythrocytes in many capillaries dropped and remained at a low level, and the number of perfused capillaries decreased. After the flow pattern was returned to pulsatile, the velocity of erythrocytes recovered to the initial level. In many cases, the flow of nonperfused capillaries recovered to the initial level as well. Also, the pulsatile flow enhances the basal and flow-stimulated endothelium-derived nitric oxide release in microvessels.

元の言語English
ページ(範囲)875-881
ページ数7
ジャーナルArtificial Organs
27
発行部数10
DOI
出版物ステータスPublished - 2003 10
外部発表Yes

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Artificial heart
Flow patterns
Microcirculation
Nitric oxide
Pumps
Nitric Oxide
Pulsatile flow
Animals
Blood

ASJC Scopus subject areas

  • Biophysics

これを引用

Evaluation of Pulsatile and Nonpulsatile Flow in Microvessels of the Bulbar Conjunctiva in the Goat with an Undulation Pump Artificial Heart. / Baba, Atsushi; Dobsak, Petr; Mochizuki, Shuichi; Saito, Itsuro; Isoyama, Takashi; Takiura, Koki; Shibata, Masahiro; Abe, Yusuke; Chinzei, Tsuneo; Vasku, Jaromir; Imachi, Kou.

:: Artificial Organs, 巻 27, 番号 10, 10.2003, p. 875-881.

研究成果: Article

Baba, A, Dobsak, P, Mochizuki, S, Saito, I, Isoyama, T, Takiura, K, Shibata, M, Abe, Y, Chinzei, T, Vasku, J & Imachi, K 2003, 'Evaluation of Pulsatile and Nonpulsatile Flow in Microvessels of the Bulbar Conjunctiva in the Goat with an Undulation Pump Artificial Heart', Artificial Organs, 巻. 27, 番号 10, pp. 875-881. https://doi.org/10.1046/j.1525-1594.2003.00027.x
Baba, Atsushi ; Dobsak, Petr ; Mochizuki, Shuichi ; Saito, Itsuro ; Isoyama, Takashi ; Takiura, Koki ; Shibata, Masahiro ; Abe, Yusuke ; Chinzei, Tsuneo ; Vasku, Jaromir ; Imachi, Kou. / Evaluation of Pulsatile and Nonpulsatile Flow in Microvessels of the Bulbar Conjunctiva in the Goat with an Undulation Pump Artificial Heart. :: Artificial Organs. 2003 ; 巻 27, 番号 10. pp. 875-881.
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