Expression of Fc receptor for immunoglobulin M in oligodendrocytes and myelin of mouse central nervous system

Jin Nakahara, Chika Seiwa, Akira Shibuya, Sadakazu Aiso, Hiroaki Asou

研究成果: Article査読

20 被引用数 (Scopus)

抄録

Recent advances in neuro-immunology are beginning to elucidate several essential roles of the humoral immunity in both repair and pathogenesis of central nervous system diseases. Immunoglobulin M (IgM) was reported to accelerate the rate of remyelination in a demyelinating disease model, while intrathecal IgM synthesis was shown to predict a more worse disease course in a human demyelinating disease, multiple sclerosis. Molecular mechanisms for either of these IgM functions remain to be studied. Here we report that a recently-found Fc receptor for IgM, namely Fcα/μR, is expressed in oligodendrocytes, their precursor cells, and myelin. These expressions were confirmed by immunocytochemistry of cultured cells, Western blot analysis of myelin fractions, and also by immunohistochemistry of mouse forebrains at different ages. Our findings suggest a possible direct interaction between IgM and Fcα/μR expressed in oligodendrocytes and myelin.

本文言語English
ページ(範囲)73-76
ページ数4
ジャーナルNeuroscience Letters
337
2
DOI
出版ステータスPublished - 2003 2 6
外部発表はい

ASJC Scopus subject areas

  • 神経科学(全般)

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