Functional imaging of cat primary visual cortex with optical coherence tomography

Uma Maheswari Rajagopalan, Hideyuki Takaoka, Ryota Homma, Hirofumi Kadono, Manabu Tanifuji

研究成果: Article査読

2 被引用数 (Scopus)


We report the application of Optical coherence tomography (OCT) for visualizing a one dimensional depth resolved functional structure of cat brain in vivo. The OCT system is based on the known fact that neural activation induces structural changes such as capillary dilation and cellular swelling. Detecting these changes as an amplitude change of the scattered light, an OCT signal reflecting neural activity i.e., fOCT (functional OCT) could be obtained. Experiments have been done to obtain a depth resolved stimulus-specific profile of activation in cat visual cortex. Our results in one dimension indicate that indeed an orientation dependent functional signal could be obtained. Further, we show that this depth resolved fOCT signal is well correlated with the stimulus dependent column determined by OISI. Based on the results, the smallest functional unit in depth, resolved by the proposed system is around 40 μm. We are extending our system to perform two dimensional functional imaging.

ジャーナルProceedings of SPIE - The International Society for Optical Engineering
出版ステータスPublished - 2002 6月 14

ASJC Scopus subject areas

  • 電子材料、光学材料、および磁性材料
  • 凝縮系物理学
  • コンピュータ サイエンスの応用
  • 応用数学
  • 電子工学および電気工学


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