Generation Mechanism of Alternans in Luo-Rudy Model

Hiroyuki Kitajima, Eri Ioka, Toru Yazawa

研究成果: Article

2 引用 (Scopus)

抜粋

Electrical alternans is the alternating amplitude from beat to beat in the action potential of the cardiac cell. It has been associated with ventricular arrhythmias in many clinical studies; however, its dynamical mechanisms remain unknown. The reason is that we do not have realistic network models of the heart system. Recently, Yazawa clarified the network structure of the heart and the central nerve system in the crustacean heart. In this study, we construct a simple model of the heart system based on Yazawa's experimental data. Using this model, we clarify that two parameters (the conductance of sodium ions and free concentration of potassium ions in the extracellular compartment) play the key roles of generating alternans. In particular, we clarify that the inactivation gate of the time-independent potassium channel is the most important parameter. Moreover, interaction between the membrane potential and potassium ionic currents is significant for generating alternate rhythms. This result indicates that if the muscle cell has problems such as channelopathies, there is great risk of generating alternans.

元の言語English
記事番号1650075
ジャーナルInternational Journal of Bifurcation and Chaos
26
発行部数5
DOI
出版物ステータスPublished - 2016 5 1
外部発表Yes

ASJC Scopus subject areas

  • Modelling and Simulation
  • Engineering(all)
  • General
  • Applied Mathematics

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