Glucose-driven Monolithic Polydimethylsiloxane Decompression Unit for Drug Release Device Using Plasma-activated Bonding Technology

Takahiro Arakawa, Koji Kurihara, Daisuke Mori, Koji Toma, Kazuyoshi Yano, Kohji Mitsubayashi

研究成果: Article査読

抄録

A new enzymatic chemomechanical actuator that can convert the chemical energy of glucose into mechanical energy for an autonomous drug release system without electrical power was developed and demonstrated. The glucose-oxidase-immobilized membrane recognized glucose and converted the chemical energy found in glucose to the mechanical energy of actuation. The decompression unit of the system consisted of an enzyme co-immobilized dialysis membrane, an ultraviolet cross-linkable polymer of polyvinyl alcohol (PVA-SbQ), and polydimethylsiloxane (PDMS) microfluidic channels. According to the evaluation of the bonding condition between PVA-SbQ and PDMS, direct bonding with different polymer materials was realized without damage to glucose oxidase (GOD). The optimized plasma treatment conditions were a sweep rate of 400 mm/s and an applied electric power of 140 W. The decompression unit had an appropriate decompression rate (2.16 Pa/s) at the glucose concentration of the blood sugar level, which was achieved by increasing the enzyme membrane area per gas phase volume. The monolithic PDMS decompression unit is promising for the development of a chemomechanical device driven by human blood sugar for diabetes treatment in the future.

本文言語English
ページ(範囲)1501-1514
ページ数14
ジャーナルSensors and Materials
34
4
DOI
出版ステータスPublished - 2022
外部発表はい

ASJC Scopus subject areas

  • 器械工学
  • 材料科学(全般)

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