TY - JOUR
T1 - Hydrolysis of phosphatidylinositol by rare earth metal ion as a phospholipase C mimic
AU - Matsumura, Kazunari
AU - Komiyama, Makoto
PY - 1994/8/1
Y1 - 1994/8/1
N2 - Phosphatidylinositol, a cell-membrane component responsible for the transduction of extracellular signals into cells, is hydrolyzed by rare earth metal chlorides (YCl3, LaCl3, EuCl3, CeCl3, and TmCl3) at pH 7.5-8.5 and 30°C. YCl3 has the largest activity. A key step in the cell-to-cell communication has been successfully mimicked. In contrast, non-rare earth metal ions such as Fe(III), Zn(II), and Cu(II) show no measurable activity, confirming the overwhelming superiority of rare earth metal(III) ions.
AB - Phosphatidylinositol, a cell-membrane component responsible for the transduction of extracellular signals into cells, is hydrolyzed by rare earth metal chlorides (YCl3, LaCl3, EuCl3, CeCl3, and TmCl3) at pH 7.5-8.5 and 30°C. YCl3 has the largest activity. A key step in the cell-to-cell communication has been successfully mimicked. In contrast, non-rare earth metal ions such as Fe(III), Zn(II), and Cu(II) show no measurable activity, confirming the overwhelming superiority of rare earth metal(III) ions.
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U2 - 10.1016/0162-0134(94)85037-2
DO - 10.1016/0162-0134(94)85037-2
M3 - Article
AN - SCOPUS:0028306084
SN - 0162-0134
VL - 55
SP - 153
EP - 156
JO - Journal of Inorganic Biochemistry
JF - Journal of Inorganic Biochemistry
IS - 2
ER -