In vivo evaluation of peripheral vascular resistance based on Poiseuille’s law

Kazuhiro Yokokawa, Saki Hamashima, Masahiro Shibata

研究成果: Article査読

抄録

To elucidate that Poiseuille's law can be applied in vivo microcirculation, we tried to analyze the total peripheral vascular resistance (Rt) and single arteriolar resistance (Ra) obtained from in vivo animal experiments. Rt and Ra values were quantified by measurements of systemic blood pressure (BP) , and by direct observation of microcirculation simultaneously. During L-NAME induced vasoconstriction, systemic BP significantly increased from 91 ± 8 mmHg to 114 ± 9 mmHg, while arterial diameter decreased from 137 ± 31 μm to 129 ± 30 μm (n = 14). The Rt and Ra values during vasoconstriction increased in 23.9 ± 10.4 % and 22.0 ± 9.9 %, respectively, which there were no significant differences. These result confirmed the Poiseuille's law is acceptable to apply for in vivo microcirculation.

本文言語English
ページ(範囲)O-432-O-433
ジャーナルTransactions of Japanese Society for Medical and Biological Engineering
52
DOI
出版ステータスPublished - 2014 8月 17

ASJC Scopus subject areas

  • 生体医工学

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