Interactions between SNP alleles at multiple loci contribute to skin color differences between caucasoid and mongoloid subjects

Sumiko Anno, Takashi Abe, Takushi Yamamoto

研究成果: Article査読

28 被引用数 (Scopus)

抄録

This study aimed to identify single nucleotide polymorphism (SNP) alleles at multiple loci associated with racial differences in skin color using SNP genotyping. A total of 122 Caucasians in Toledo, Ohio and 100 Mongoloids in Japan were genotyped for 20 SNPs in 7 candidate genes, encoding the Agouti signaling protein (ASIP), tyrosinase-related protein 1 (TYRP1), tyrosinase (TYR), melanocortin 1 receptor (MC1R), oculocutaneous albinism II (OCA2), microphthalmia-associated transcription factor (MITF), and myosin VA (MYO5A). Data were used to analyze associations between the 20 SNP alleles using linkage disequilibrium (LD). Combinations of SNP alleles were jointly tested under LD for associations with racial groups by performing a χ2 test for independence. Results showed that SNP alleles at multiple loci can be considered the haplotype that contributes to significant differences between the two population groups and suggest a high probability of LD. Confirmation of these findings requires further study with other ethnic groups to analyze the associations between SNP alleles at multiple loci and skin color variation among races.

本文言語English
ページ(範囲)81-86
ページ数6
ジャーナルInternational Journal of Biological Sciences
4
2
DOI
出版ステータスPublished - 2008 3 31

ASJC Scopus subject areas

  • 生態、進化、行動および分類学
  • 応用微生物学とバイオテクノロジー
  • 分子生物学
  • 発生生物学
  • 細胞生物学

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