TY - GEN

T1 - Intravascular shear stress imaging based on ultrasonic velocity vector measurement

AU - Nitta, Naotaka

AU - Homma, Kazuhiro

AU - Shiina, Tsuyoshi

PY - 2005

Y1 - 2005

N2 - It has been reported that the wall shear stress affects the biochemical function of endothelial cell and the development of arteriosclerosis plaque. Therefore, the quantitative estimation of the wall shear stress has possibilities to be useful for the prevention of arteriosclerosis. In this paper, a novel method for the real-time and quantitative estimation of intravascular shear stress distribution is proposed based on the estimates of the viscosity and the shear rate distribution. Experimental investigation, in which two types of fluids with different viscosity coefficient (water, and water mixed by PVA) flowed at a constant flow rate in a silicone tube with a simulated arteriosclerosis plaque, was performed. After estimating the viscosity coefficient and the shear rate distribution based on the ultrasonic measurements of the velocity vector distribution in the tube, the shear stress distributions were obtained. The averaged value of the shear stress distribution estimated in the higher viscosity fluid (water mixed by PVA: 0.3 Pa) became larger than that in the lower viscosity fluid (water: 0.1 Pa). These results reveal that the proposed method is technically valid for the quantitative shear stress estimation.

AB - It has been reported that the wall shear stress affects the biochemical function of endothelial cell and the development of arteriosclerosis plaque. Therefore, the quantitative estimation of the wall shear stress has possibilities to be useful for the prevention of arteriosclerosis. In this paper, a novel method for the real-time and quantitative estimation of intravascular shear stress distribution is proposed based on the estimates of the viscosity and the shear rate distribution. Experimental investigation, in which two types of fluids with different viscosity coefficient (water, and water mixed by PVA) flowed at a constant flow rate in a silicone tube with a simulated arteriosclerosis plaque, was performed. After estimating the viscosity coefficient and the shear rate distribution based on the ultrasonic measurements of the velocity vector distribution in the tube, the shear stress distributions were obtained. The averaged value of the shear stress distribution estimated in the higher viscosity fluid (water mixed by PVA: 0.3 Pa) became larger than that in the lower viscosity fluid (water: 0.1 Pa). These results reveal that the proposed method is technically valid for the quantitative shear stress estimation.

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U2 - 10.1109/ULTSYM.2005.1602905

DO - 10.1109/ULTSYM.2005.1602905

M3 - Conference contribution

AN - SCOPUS:33847097912

SN - 0780393821

SN - 9780780393820

T3 - Proceedings - IEEE Ultrasonics Symposium

SP - 520

EP - 523

BT - 2005 IEEE Ultrasonics Symposium

T2 - 2005 IEEE Ultrasonics Symposium

Y2 - 18 September 2005 through 21 September 2005

ER -