Laser-driven short-duration heating angioplasty: Dilatation performance in cadaver atherosclerotic femoral arteries

Natsumi Shimazaki, Sho Naruse, Tsunenori Arai, Nobuaki Imanishi, Sadakazu Aiso

研究成果: Conference contribution


The purpose of this study was to investigate the artery dilatation performance of the short-duration heating balloon catheter in cadaver stenotic arteries. We designed a prototype short-duration heating balloon catheter that can heat artery media to around 60 °C in 15-25 s by a combination of laser-driven heat generation and continuous fluid irrigation in the balloon. We performed ex vivo short-duration heating dilatation in the cadaver atherosclerotic femoral arteries (initial percent diameter stenosis was 36-98%), with the maximum balloon temperature of 65±5 °C, laser irradiation duration of 25 s, and balloon dilatation pressure of 3.5 atm. The artery lumen configurations before and after the dilatations were assessed with a commercial IVUS system. After the short-duration heating dilatations, the percent diameter stenosis was reduced below 30% without any artery tears or dissections. We estimated that the artery media temperature was raised to around 60 °C in which plaque thickness was below 0.8 mm by a thermal conduction calculation. The estimated maximum temperature in artery adventitia and surrounding tissue was up to 45 °C. We found that the short-duration heating balloon could sufficiently dilate the cadaver stenotic arteries, without thermal injury in artery adventitia and surroundings.

ホスト出版物のタイトルPhotonic Therapeutics and Diagnostics IX
出版ステータスPublished - 2013 5月 30
イベントPhotonic Therapeutics and Diagnostics IX - San Francisco, CA, United States
継続期間: 2013 2月 22013 2月 7


名前Progress in Biomedical Optics and Imaging - Proceedings of SPIE


OtherPhotonic Therapeutics and Diagnostics IX
国/地域United States
CitySan Francisco, CA

ASJC Scopus subject areas

  • 電子材料、光学材料、および磁性材料
  • 生体材料
  • 原子分子物理学および光学
  • 放射線学、核医学およびイメージング


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