Mapping viscoelastic properties by multi-line (ML) acoustic radiation force

Mikako Gomyo, Kengo Kondo, Makoto Yamakawa, Tsuyoshi Shiina

研究成果: Conference contribution

抄録

In these days ultrasound studies of non-invasive diagnostic methods using the elastic property of tissue have showed very promising results. Biological soft tissues are viscoelastic in nature; therefore several recent studies have shown the feasibility of shear wave dispersion in order to express viscosity which is considered to be valid for early diagnoses. Shear wave Dispersion Ultrasound Vibrometry (SDUV) has been conducted under ex vivo and in vivo conditions, which could estimate the value of shear elasticity and viscosity from a 40 x 40 mm2 area. In this study, our proposed Multi-line (ML) acoustic radiation force method could map shear elasticity and viscosity at 0.2 x 0.2 mm2 pixel in 25.6 mm width and 29.6 mm depth area. ML uses seven focus points in depth to create much planar shear wave than ever, and twenty pushing line to obtain data such a broader area than ever. These sequences contribute to express precise values of shear elasticity and viscosity at each pixel. A 10% gelatin phantom with a 10% gelatin and 1% xanthan gum mixture inclusion was prepared for ML experiment, and one homogenous phantom made of the same concentrations as the background of ML experiments was for ML and SDUV experiments three times to validate. The ML measurement resulted μ41 = 1.129±0.118 kPa, μ42 = 0.893±0.090 Pas in the 10% gelatin background; their corresponding SDUV measurement were μ41 = 1.250±0.129 kPa, μ42 = 0.833±0.098 Pas in 10% gelatin phantom. Though further evaluations such as frequency and rheological model are required, the results could show the effectiveness of this proposed method in mapping viscoelasticity and the feasibility of in vivo and ex vivo experiments.

本文言語English
ホスト出版物のタイトルMedical Imaging 2015
ホスト出版物のサブタイトルUltrasonic Imaging and Tomography
編集者Neb Duric, Johan G. Bosch
出版社SPIE
ISBN(電子版)9781628415094
DOI
出版ステータスPublished - 2015
外部発表はい
イベントMedical Imaging 2015: Ultrasonic Imaging and Tomography - Orlando, United States
継続期間: 2015 2月 222015 2月 23

出版物シリーズ

名前Progress in Biomedical Optics and Imaging - Proceedings of SPIE
9419
ISSN(印刷版)1605-7422

Conference

ConferenceMedical Imaging 2015: Ultrasonic Imaging and Tomography
国/地域United States
CityOrlando
Period15/2/2215/2/23

ASJC Scopus subject areas

  • 電子材料、光学材料、および磁性材料
  • 生体材料
  • 原子分子物理学および光学
  • 放射線学、核医学およびイメージング

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