Mechanoreception in motile flagella of Chlamydomonas

Kenta Fujiu, Yoshitaka Nakayama, Hidetoshi Iida, Masahiro Sokabe, Kenjiro Yoshimura

研究成果: Article

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Ciliates and flagellates temporarily swim backwards on collision by generating a mechanoreceptor potential. Although this potential has been shown to be associated with cilia in Paramecium, the molecular entity of the mechanoreceptor has remained unknown. Here we show that Chlamydomonas cells express TRP11, a member of the TRP (transient receptor potential) subfamily V, in the proximal region of the flagella, and that suppression of TRP11 expression results in loss of the avoiding reaction. The results indicate that Chlamydomonas flagella exhibit mechanosensitivity, despite constant motility, by localizing the mechanoreceptor in the proximal region, where active bending is restricted.

元の言語English
ページ(範囲)630-632
ページ数3
ジャーナルNature Cell Biology
13
発行部数5
DOI
出版物ステータスPublished - 2011 5 1

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ASJC Scopus subject areas

  • Cell Biology

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