Microfluidic long-term cell culture platform with cell-cell interaction monitoring using surface acoustic wave

Atsushi Takano, Tasuku Kon, Yasubumi Furuya, Katsumi Mochitate, Masato Tanaka, Nobuyuki Futai

研究成果: Conference contribution

抄録

We have developed a poly(dimethylsiloxane) (PDMS)-made microfluidic long-term cell culture platform having two cell culture wells with piezoelectric substrate bottom on which shear horizontal surface acoustic wave (SH-SAW) propagates. The SH-SAW propagates on the cells could be used to assay cell-cell and/or cell-surface interaction. The platform also enables optical observation of the cells and acquisition of SH-SAW signals simultaneously. The combination of the on-chip CO2 incubation and SH-SAW-based cell monitoring system successfully detected a long-term change in cell-cell or cell-substrate interaction induced by hydrogen peroxide (H2O2).

本文言語English
ホスト出版物のタイトル2013 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2013
出版社IEEE Computer Society
ISBN(印刷版)9781479915293
DOI
出版ステータスPublished - 2013 1 1
イベント2013 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2013 - Nagoya, Japan
継続期間: 2013 11 102013 11 13

出版物シリーズ

名前2013 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2013

Conference

Conference2013 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2013
CountryJapan
CityNagoya
Period13/11/1013/11/13

ASJC Scopus subject areas

  • Electrical and Electronic Engineering

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