Microfluidic model of bubble lodging in microvessel bifurcations

Andŕs J. Calderón; Yun Seok Heo; Dongeun Huh; Nobuyuki Futai; Shuichi Takayama; J. Brian Fowlkes; Joseph L. Bull

doi:10.1063/1.2402898

Microfluidic model of bubble lodging in microvessel bifurcations

Andŕs J. Calderón, Yun Seok Heo, Dongeun Huh, Nobuyuki Futai, Shuichi Takayama, J. Brian Fowlkes, Joseph L. Bull

研究成果: Article › 査読

40 被引用数 (Scopus)

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The lodging mechanisms and dynamics of cardiovascular gas bubbles are investigated in microfluidic model bifurcations made of poly(dimethylsiloxane). This work is motivated by gas embolotherapy for the potential treatment of cancer by tumor infarction. The results show that the critical driving pressure below which a bubble will lodge in a bifurcation is significantly less than the driving pressure required to dislodge it. From the results the authors estimate that gas bubbles from embolotherapy can lodge in vessels 20 μm or smaller in diameter, and conclude that bubbles may potentially be used to reduce blood flow to tumor microcirculation.

本文言語	English
論文番号	244103
ジャーナル	Applied Physics Letters
巻	89
号	24
DOI	https://doi.org/10.1063/1.2402898
出版ステータス	Published - 2006
外部発表	はい

ASJC Scopus subject areas

物理学および天文学（その他）

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10.1063/1.2402898

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title = "Microfluidic model of bubble lodging in microvessel bifurcations",

abstract = "The lodging mechanisms and dynamics of cardiovascular gas bubbles are investigated in microfluidic model bifurcations made of poly(dimethylsiloxane). This work is motivated by gas embolotherapy for the potential treatment of cancer by tumor infarction. The results show that the critical driving pressure below which a bubble will lodge in a bifurcation is significantly less than the driving pressure required to dislodge it. From the results the authors estimate that gas bubbles from embolotherapy can lodge in vessels 20 μm or smaller in diameter, and conclude that bubbles may potentially be used to reduce blood flow to tumor microcirculation.",

author = "Calder{\'o}n, {And{\'r}s J.} and Heo, {Yun Seok} and Dongeun Huh and Nobuyuki Futai and Shuichi Takayama and Fowlkes, {J. Brian} and Bull, {Joseph L.}",

note = "Funding Information: This work was funded by NIH (EB003541 and HL084370) and NSF (BES-0301278).",

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AU - Calderón, Andŕs J.

AU - Heo, Yun Seok

AU - Huh, Dongeun

AU - Futai, Nobuyuki

AU - Takayama, Shuichi

AU - Fowlkes, J. Brian

AU - Bull, Joseph L.

N1 - Funding Information: This work was funded by NIH (EB003541 and HL084370) and NSF (BES-0301278).

PY - 2006

Y1 - 2006

N2 - The lodging mechanisms and dynamics of cardiovascular gas bubbles are investigated in microfluidic model bifurcations made of poly(dimethylsiloxane). This work is motivated by gas embolotherapy for the potential treatment of cancer by tumor infarction. The results show that the critical driving pressure below which a bubble will lodge in a bifurcation is significantly less than the driving pressure required to dislodge it. From the results the authors estimate that gas bubbles from embolotherapy can lodge in vessels 20 μm or smaller in diameter, and conclude that bubbles may potentially be used to reduce blood flow to tumor microcirculation.

AB - The lodging mechanisms and dynamics of cardiovascular gas bubbles are investigated in microfluidic model bifurcations made of poly(dimethylsiloxane). This work is motivated by gas embolotherapy for the potential treatment of cancer by tumor infarction. The results show that the critical driving pressure below which a bubble will lodge in a bifurcation is significantly less than the driving pressure required to dislodge it. From the results the authors estimate that gas bubbles from embolotherapy can lodge in vessels 20 μm or smaller in diameter, and conclude that bubbles may potentially be used to reduce blood flow to tumor microcirculation.

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Microfluidic model of bubble lodging in microvessel bifurcations

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