Microfluidic model of bubble lodging in microvessel bifurcations

Andŕs J. Calderón, Yun Seok Heo, Dongeun Huh, Nobuyuki Futai, Shuichi Takayama, J. Brian Fowlkes, Joseph L. Bull

研究成果: Article査読

36 被引用数 (Scopus)

抄録

The lodging mechanisms and dynamics of cardiovascular gas bubbles are investigated in microfluidic model bifurcations made of poly(dimethylsiloxane). This work is motivated by gas embolotherapy for the potential treatment of cancer by tumor infarction. The results show that the critical driving pressure below which a bubble will lodge in a bifurcation is significantly less than the driving pressure required to dislodge it. From the results the authors estimate that gas bubbles from embolotherapy can lodge in vessels 20 μm or smaller in diameter, and conclude that bubbles may potentially be used to reduce blood flow to tumor microcirculation.

本文言語English
論文番号244103
ジャーナルApplied Physics Letters
89
24
DOI
出版ステータスPublished - 2006
外部発表はい

ASJC Scopus subject areas

  • 物理学および天文学(その他)

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