Monoclonal anti-tumor necrosis factor antibody renders non-obese diabetic mice hypersensitive to irradiation and enhances insulitis development

Chalm O. Jacob, Sadakazu Aiso, Robert D. Schreiber, Hugh O. Mcdevitt

研究成果: Article査読

44 被引用数 (Scopus)

抄録

In attempt to evaluate biological roles of tumor necrosis factor (TNF), we studied the effects of anti-TNF mAb in non-obese diabetic (NOD) mice. Anti-murine TNF mAb rendered NOD mice hypersensitive to the lethal effects of radiation and prevented the reconstitution of lethally Irradiated mice with adoptively transferred lymphocytes. While TNF-α reduced the incidence of diabetes development in the adoptive transfer system even when given 6 days post-transfer, mAb to TNF could not reduce or increase the incidence of diabetes compared to control mice. Administration of TNF-α for 4 or 8 weeks significantly reduced the Incidence of spontaneous Insulitis in NOD mice, while antl-TNF mAb given for 8 weeks Increased the Incidence of insulltls significantly.

本文言語English
ページ(範囲)611-614
ページ数4
ジャーナルInternational Immunology
4
5
DOI
出版ステータスPublished - 1992 5
外部発表はい

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

フィンガープリント 「Monoclonal anti-tumor necrosis factor antibody renders non-obese diabetic mice hypersensitive to irradiation and enhances insulitis development」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル