mRNA sequence of the Xenopus laevis paxillin gene and its expression

Motoyuki Ogawa, Yoshiki Hiraoka, Koji Taniguchi, Yukinao Sakai, Sadakazu Aiso

研究成果: Article査読

8 被引用数 (Scopus)

抄録

Paxillin is a cytoskeletal protein found in structures of focal adhesions where cells adhere to the extracellular matrix. We isolated paxillin cDNA from the Xenopus laevis ovary. The cDNA sequence encodes a protein of 539 amino acids with four LIM and five LD motifs. 80% of the amino acids of frog paxillin are shared by human and chicken paxillins. Northern analysis showed that the frog gene is expressed in the spleen, kidney, testis and ovary. Immunocytochemistry showed that paxillin protein is accumulated in the nucleus as well as in the periphery of the cytoplasm of the A6 cell. This intriguing result shows that paxillin, which has been characterized as a cytoskeletal protein, is capable of translocating to the nucleus.

本文言語English
ページ(範囲)235-240
ページ数6
ジャーナルBiochimica et Biophysica Acta - Gene Structure and Expression
1519
3
DOI
出版ステータスPublished - 2001 6 28
外部発表はい

ASJC Scopus subject areas

  • 構造生物学
  • 生物理学
  • 生化学
  • 遺伝学

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