N-C Axially Chiral Compounds with an ortho-Fluoro Substituent and Steric Discrimination between Hydrogen and Fluorine Atoms Based on a Diastereoselective Model Reaction

Asumi Iida, Mizuki Matsuoka, Hiroshi Hasegawa, Nicolas Vanthuyne, Daniel Farran, Christian Roussel, Osamu Kitagawa

研究成果: Article査読

3 被引用数 (Scopus)

抄録

The fluorine atom is the second smallest atom; nevertheless, the ortho-fluoro group may lead to stable N-aryl atropisomers when the steric demand of the flanking substituents is large enough. 2-Alkyl-3-(2-fluorophenyl)quinazolin-4-ones and 3-(2-fluorophenyl)-4-methylthiazoline-2-thione were found to be the first N-aryl axially chiral compounds bearing an ortho-fluoro group whose enantiomers were isolated at ambient temperature. The reaction of alkyl halides with the anionic species prepared from 2-ethyl-3-(2-fluorophenyl)quinazolin-4-one presenting an N-C axial chirality provided a model reaction for quantitative evaluation of the steric discrimination (slight difference of steric factor) between hydrogen and fluorine atoms. In the case of low steric demand (allylation reaction) no diastereoselectivity was detected, while in the case of high steric demand (isopropylation reaction) the diastereoselectivity became significant.

本文言語English
ページ(範囲)3169-3175
ページ数7
ジャーナルJournal of Organic Chemistry
84
6
DOI
出版ステータスPublished - 2019 3 15

ASJC Scopus subject areas

  • Organic Chemistry

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