Naturally occurring UBIAD1 mutations differentially affect menaquinone biosynthesis and vitamin K-dependent carboxylation

Medicine & Life Sciences

• Dimethylallyltranstransferase 100%
• Vitamin K 2 79%
• Corneal Dystrophy, Crystalline, of Schnyder 70%
• Vitamin K 67%
• Protein Domains 58%
• Mutation 32%
• menatetrenone 12%
• Gene Knock-In Techniques 12%
• Gene Editing 8%
• Phenotype 8%
• Clustered Regularly Interspaced Short Palindromic Repeats 8%
• Proteins 7%
• HEK293 Cells 7%
• Genetic Variation 6%
• Cornea 6%
• Cholesterol 5%
• In Vitro Techniques 3%
• Genes 2%

Chemical Compounds

• Menaquinone 88%
• Carboxylation 70%
• Vitamin 58%
• Mutation 48%
• Biosynthesis 48%
• Cofactor 6%
• Cholesterol 6%
• Protein 5%