Non-equilibrium atmospheric pressure plasmas modulate cell cycle-related gene expressions in melanocytic tumors of RET-transgenic mice

Ichiro Yajima, Machiko Iida, Mayuko Y. Kumasaka, Yasuhiro Omata, Nobutaka Ohgami, Jie Chang, Sahoko Ichihara, Masaru Hori, Masashi Kato

研究成果: Article

24 引用 (Scopus)

抄録

The incidence of cutaneous malignant melanoma is increasing at a greater rate than that of any other cancer in the world. However, an effective therapy for malignant melanoma has not been established. Recently, some studies have shown an antitumor effect of non-equilibrium atmospheric pressure plasmas (NEAPPs) in vitro. Here, we examined the in vivo effect of NEAPP on cell cycle regulators, key elements for malignant transformation, in spontaneously developed benign melanocytic tumors in a hairless animal model. NEAPP irradiation decreased expression levels of cell cycle promoters, Cyclin D1, E1 and E2, and increased expression level of a cell cycle repressor, p27KIP1. Cyclin D1, E1 and E2 and p27KIP expression levels were associated with malignant transformation of the benign tumor in the animal model. Our results suggest that NEAPP irradiation suppresses malignant transformation of a benign melanocytic tumor via control of the expression levels of cell cycle regulators.

元の言語English
ページ(範囲)424-425
ページ数2
ジャーナルExperimental Dermatology
23
発行部数6
DOI
出版物ステータスPublished - 2014 1 1
外部発表Yes

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Gene expression
Atmospheric pressure
Tumors
Cells
Plasmas
Cyclin D1
Animals
Irradiation

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology

これを引用

Non-equilibrium atmospheric pressure plasmas modulate cell cycle-related gene expressions in melanocytic tumors of RET-transgenic mice. / Yajima, Ichiro; Iida, Machiko; Kumasaka, Mayuko Y.; Omata, Yasuhiro; Ohgami, Nobutaka; Chang, Jie; Ichihara, Sahoko; Hori, Masaru; Kato, Masashi.

:: Experimental Dermatology, 巻 23, 番号 6, 01.01.2014, p. 424-425.

研究成果: Article

Yajima, Ichiro ; Iida, Machiko ; Kumasaka, Mayuko Y. ; Omata, Yasuhiro ; Ohgami, Nobutaka ; Chang, Jie ; Ichihara, Sahoko ; Hori, Masaru ; Kato, Masashi. / Non-equilibrium atmospheric pressure plasmas modulate cell cycle-related gene expressions in melanocytic tumors of RET-transgenic mice. :: Experimental Dermatology. 2014 ; 巻 23, 番号 6. pp. 424-425.
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abstract = "The incidence of cutaneous malignant melanoma is increasing at a greater rate than that of any other cancer in the world. However, an effective therapy for malignant melanoma has not been established. Recently, some studies have shown an antitumor effect of non-equilibrium atmospheric pressure plasmas (NEAPPs) in vitro. Here, we examined the in vivo effect of NEAPP on cell cycle regulators, key elements for malignant transformation, in spontaneously developed benign melanocytic tumors in a hairless animal model. NEAPP irradiation decreased expression levels of cell cycle promoters, Cyclin D1, E1 and E2, and increased expression level of a cell cycle repressor, p27KIP1. Cyclin D1, E1 and E2 and p27KIP expression levels were associated with malignant transformation of the benign tumor in the animal model. Our results suggest that NEAPP irradiation suppresses malignant transformation of a benign melanocytic tumor via control of the expression levels of cell cycle regulators.",
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AU - Yajima, Ichiro

AU - Iida, Machiko

AU - Kumasaka, Mayuko Y.

AU - Omata, Yasuhiro

AU - Ohgami, Nobutaka

AU - Chang, Jie

AU - Ichihara, Sahoko

AU - Hori, Masaru

AU - Kato, Masashi

PY - 2014/1/1

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N2 - The incidence of cutaneous malignant melanoma is increasing at a greater rate than that of any other cancer in the world. However, an effective therapy for malignant melanoma has not been established. Recently, some studies have shown an antitumor effect of non-equilibrium atmospheric pressure plasmas (NEAPPs) in vitro. Here, we examined the in vivo effect of NEAPP on cell cycle regulators, key elements for malignant transformation, in spontaneously developed benign melanocytic tumors in a hairless animal model. NEAPP irradiation decreased expression levels of cell cycle promoters, Cyclin D1, E1 and E2, and increased expression level of a cell cycle repressor, p27KIP1. Cyclin D1, E1 and E2 and p27KIP expression levels were associated with malignant transformation of the benign tumor in the animal model. Our results suggest that NEAPP irradiation suppresses malignant transformation of a benign melanocytic tumor via control of the expression levels of cell cycle regulators.

AB - The incidence of cutaneous malignant melanoma is increasing at a greater rate than that of any other cancer in the world. However, an effective therapy for malignant melanoma has not been established. Recently, some studies have shown an antitumor effect of non-equilibrium atmospheric pressure plasmas (NEAPPs) in vitro. Here, we examined the in vivo effect of NEAPP on cell cycle regulators, key elements for malignant transformation, in spontaneously developed benign melanocytic tumors in a hairless animal model. NEAPP irradiation decreased expression levels of cell cycle promoters, Cyclin D1, E1 and E2, and increased expression level of a cell cycle repressor, p27KIP1. Cyclin D1, E1 and E2 and p27KIP expression levels were associated with malignant transformation of the benign tumor in the animal model. Our results suggest that NEAPP irradiation suppresses malignant transformation of a benign melanocytic tumor via control of the expression levels of cell cycle regulators.

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KW - Melanoma

KW - Non-equilibrium atmospheric pressure plasma

KW - RET

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