抄録
The incidence of cutaneous malignant melanoma is increasing at a greater rate than that of any other cancer in the world. However, an effective therapy for malignant melanoma has not been established. Recently, some studies have shown an antitumor effect of non-equilibrium atmospheric pressure plasmas (NEAPPs) in vitro. Here, we examined the in vivo effect of NEAPP on cell cycle regulators, key elements for malignant transformation, in spontaneously developed benign melanocytic tumors in a hairless animal model. NEAPP irradiation decreased expression levels of cell cycle promoters, Cyclin D1, E1 and E2, and increased expression level of a cell cycle repressor, p27KIP1. Cyclin D1, E1 and E2 and p27KIP expression levels were associated with malignant transformation of the benign tumor in the animal model. Our results suggest that NEAPP irradiation suppresses malignant transformation of a benign melanocytic tumor via control of the expression levels of cell cycle regulators.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 424-425 |
| ページ数 | 2 |
| ジャーナル | Experimental Dermatology |
| 巻 | 23 |
| 発行部数 | 6 |
| DOI | |
| 出版物ステータス | Published - 2014 1 1 |
| 外部発表 | Yes |
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ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Dermatology
これを引用
Non-equilibrium atmospheric pressure plasmas modulate cell cycle-related gene expressions in melanocytic tumors of RET-transgenic mice. / Yajima, Ichiro; Iida, Machiko; Kumasaka, Mayuko Y.; Omata, Yasuhiro; Ohgami, Nobutaka; Chang, Jie; Ichihara, Sahoko; Hori, Masaru; Kato, Masashi.
：: Experimental Dermatology, 巻 23, 番号 6, 01.01.2014, p. 424-425.研究成果: Article
}
TY - JOUR
T1 - Non-equilibrium atmospheric pressure plasmas modulate cell cycle-related gene expressions in melanocytic tumors of RET-transgenic mice
AU - Yajima, Ichiro
AU - Iida, Machiko
AU - Kumasaka, Mayuko Y.
AU - Omata, Yasuhiro
AU - Ohgami, Nobutaka
AU - Chang, Jie
AU - Ichihara, Sahoko
AU - Hori, Masaru
AU - Kato, Masashi
PY - 2014/1/1
Y1 - 2014/1/1
N2 - The incidence of cutaneous malignant melanoma is increasing at a greater rate than that of any other cancer in the world. However, an effective therapy for malignant melanoma has not been established. Recently, some studies have shown an antitumor effect of non-equilibrium atmospheric pressure plasmas (NEAPPs) in vitro. Here, we examined the in vivo effect of NEAPP on cell cycle regulators, key elements for malignant transformation, in spontaneously developed benign melanocytic tumors in a hairless animal model. NEAPP irradiation decreased expression levels of cell cycle promoters, Cyclin D1, E1 and E2, and increased expression level of a cell cycle repressor, p27KIP1. Cyclin D1, E1 and E2 and p27KIP expression levels were associated with malignant transformation of the benign tumor in the animal model. Our results suggest that NEAPP irradiation suppresses malignant transformation of a benign melanocytic tumor via control of the expression levels of cell cycle regulators.
AB - The incidence of cutaneous malignant melanoma is increasing at a greater rate than that of any other cancer in the world. However, an effective therapy for malignant melanoma has not been established. Recently, some studies have shown an antitumor effect of non-equilibrium atmospheric pressure plasmas (NEAPPs) in vitro. Here, we examined the in vivo effect of NEAPP on cell cycle regulators, key elements for malignant transformation, in spontaneously developed benign melanocytic tumors in a hairless animal model. NEAPP irradiation decreased expression levels of cell cycle promoters, Cyclin D1, E1 and E2, and increased expression level of a cell cycle repressor, p27KIP1. Cyclin D1, E1 and E2 and p27KIP expression levels were associated with malignant transformation of the benign tumor in the animal model. Our results suggest that NEAPP irradiation suppresses malignant transformation of a benign melanocytic tumor via control of the expression levels of cell cycle regulators.
KW - Cell cycle
KW - Melanoma
KW - Non-equilibrium atmospheric pressure plasma
KW - RET
UR - http://www.scopus.com/inward/record.url?scp=84901506111&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84901506111&partnerID=8YFLogxK
U2 - 10.1111/exd.12415
DO - 10.1111/exd.12415
M3 - Article
C2 - 24750453
AN - SCOPUS:84901506111
VL - 23
SP - 424
EP - 425
JO - Experimental Dermatology
JF - Experimental Dermatology
SN - 0906-6705
IS - 6
ER -