Novel ninhydrin adduct of catechin with potent antioxidative activity

Kiyoshi Fukuhara, Akiko Ohno, Ikuo Nakanishi, Kohei Imai, Asao Nakamura, Kazunori Anzai, Naoki Miyata, Haruhiro Okuda

研究成果: Article

7 引用 (Scopus)

抜粋

The reaction of ninhydrin with (+)-catechin in the presence of TMSOTf resulted in condensation product 1, which consists of a 2:1 mixture of epimers at the C-2 position. The antioxidative radical-scavenging activity of 1 against the galvinoxyl radical, acting as an oxyl radical, was significantly enhanced compared to (+)-catechin. Our results offer a new method for chemical modification of a natural phenolic antioxidant.

元の言語English
ページ(範囲)6989-6992
ページ数4
ジャーナルTetrahedron Letters
50
発行部数50
DOI
出版物ステータスPublished - 2009 12 16

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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    Fukuhara, K., Ohno, A., Nakanishi, I., Imai, K., Nakamura, A., Anzai, K., Miyata, N., & Okuda, H. (2009). Novel ninhydrin adduct of catechin with potent antioxidative activity. Tetrahedron Letters, 50(50), 6989-6992. https://doi.org/10.1016/j.tetlet.2009.09.149