Optical characteristics of human skin with hyperpigmentation caused by fluorinated pyrimidine anticancer agent

Takahiro Kono, Nobuaki Imanishi, Keiko Nozawa, Atsuo Takashima, Rajagopalan Uma Maheswari, Hiroki Gonome, Jun Yamada

研究成果: Article

抜粋

The fluorinated pyrimidine anticancer agent has several side effects that degrade the quality of life of patients, including hyperpigmentation. Hyperpigmentation differs in color from common pigmentation such as a suntan, giving rise to dramatic skin appearance changes. In this study, we measured the optical properties of the skin of patients with hyperpigmentation by using the reflection spatial profile method (RSPM). The absorption coefficient in hyperpigmentation increased ~1.5–2.5 times and pheomelanin significantly increased compared to the normal skin. In addition, the scattering coefficient of skin with hyperpigmentation was about 65.9–76.5% of that of normal skin.

元の言語English
記事番号366571
ページ(範囲)3747-3759
ページ数13
ジャーナルBiomedical Optics Express
10
発行部数8
DOI
出版物ステータスPublished - 2019 8 1

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics

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