Optimization of islet microencapsulation with thin polymer membranes for long-term stability

Shota Toda, Artin Fattah, Kenta Asawa, Naoko Nakamura, Kristina N. Ekdahl, Bo Nilsson, Yuji Teramura

研究成果: Article

抜粋

Microencapsulation of islets can protect against immune reactions from the host immune system after transplantation. However, sufficient numbers of islets cannot be transplanted due to the increase of the size and total volume. Therefore, thin and stable polymer membranes are required for the microencapsulation. Here, we undertook the cell microencapsulation using poly(ethylene glycol)-conjugated phospholipid (PEG-lipid) and layer-by-layer membrane of multiple-arm PEG. In order to examine the membrane stability, we used different molecular weights of 4-arm PEG (10k, 20k and 40k)-Mal to examine the influence on the polymer membrane stability. We found that the polymer membrane made of 4-arm PEG(40k)-Mal showed the highest stability on the cell surface. Also, the polymer membrane did not disturb the insulin secretion from beta cells.

元の言語English
記事番号755
ジャーナルMicromachines
10
発行部数11
DOI
出版物ステータスPublished - 2019 11 1

ASJC Scopus subject areas

  • Control and Systems Engineering
  • Mechanical Engineering
  • Electrical and Electronic Engineering

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  • これを引用

    Toda, S., Fattah, A., Asawa, K., Nakamura, N., Ekdahl, K. N., Nilsson, B., & Teramura, Y. (2019). Optimization of islet microencapsulation with thin polymer membranes for long-term stability. Micromachines, 10(11), [755]. https://doi.org/10.3390/mi10110755