Oxygen consumption of keloids and hypertrophic scars

Shigeru Ichioka, Taichi Ando, Masahiro Shibata, Naomi Sekiya, Takashi Nakatsuka

研究成果査読

26 被引用数 (Scopus)

抄録

The oxygen consumption of keloids and hypertrophic scars has never been quantitatively presented, although abnormal metabolic conditions must be associated with their pathophysiology. We invented an original measurement system equipped with a Clark oxygen electrode for ex vivo samples. The measurement of a mouse wound-healing model revealed immature repairing tissues consumed more oxygen than mature tissues. This finding is in accord with the current thinking and supported the validity of our measurement system. The analysis of fresh human samples clearly demonstrated the high oxygen consumption rate of keloid hypertrophic scars and the comparatively low consumption of mature scars. A high oxygen consuming potential, as well as insufficient oxygen diffusion, may possibly contribute to the pathophysiology of keloids and hypertrophic scars.

本文言語English
ページ(範囲)194-197
ページ数4
ジャーナルAnnals of Plastic Surgery
60
2
DOI
出版ステータスPublished - 2008 2

ASJC Scopus subject areas

  • 外科

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