Photoacoustic lymphangiography

Hiroki Kajita, Anna Oh, Moemi Urano, Masashi Takemaru, Nobuaki Imanishi, Marika Otaki, Takayuki Yagi, Sadakazu Aiso, Kazuo Kishi

研究成果: Article

抜粋

Background and objectives: Photoacoustic lymphangiography, which is based on photoacoustic technology, is an optical imaging that visualizes the distribution of light absorbing tissue components like hemoglobin or melanin, as well as optical absorption contrast imaging agents like indocyanine green (ICG) in the lymphatic channels, with high spatial resolution. In this report, we introduce the three-dimensional (3D) images of human lymphatic vessels obtained with photoacoustic lymphangiography. Methods: We used the 3D photoacoustic visualization system (PAI-05). Some healthy subjects and lymphedema patients were recruited. To image the lymphatic structures of the limbs ICG was administered subcutaneously as in fluorescence lymphangiography. Photoacoustic images were acquired by irradiating the tissue using a laser at wavelengths of near-infrared region. On the same occasion, fluorescence images were also recorded. Results: The lymphatic vessels up to the diameter of 0.2 mm could be observed three-dimensionally with the venules around them. In the patient-group, dermal backflow patterns were often observed as dense interconnecting 3D structures of lymphatic vessels. Collecting vessels passing below the dermis were also observed, which were not observed by fluorescence lymphography. Conclusions: Photoacoustic lymphangiography provided the detailed observation of each lymphatic vessel, leading to deeper understanding of 3D structures and physiological state of the vessel.

元の言語English
ページ(範囲)48-50
ページ数3
ジャーナルJournal of Surgical Oncology
121
発行部数1
DOI
出版物ステータスPublished - 2020 1 1

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ASJC Scopus subject areas

  • Surgery
  • Oncology

これを引用

Kajita, H., Oh, A., Urano, M., Takemaru, M., Imanishi, N., Otaki, M., ... Kishi, K. (2020). Photoacoustic lymphangiography. Journal of Surgical Oncology, 121(1), 48-50. https://doi.org/10.1002/jso.25575