Physiological role of nitric oxide in oxygen consumption by arteriolar wall

Masahiro Shibata, Takehiro Yamakoshi, Ken Ichi Yamakoshi

研究成果: Conference contribution

1 引用 (Scopus)

抜粋

To study the role of nitric oxide (NO) in regulating oxygen consumption by vessel walls, the oxygen consumption rate of arteriolar walls in rat cremaster muscle was measured in vivo during flow-induced vasodilation and after inhibiting NO synthesis. The oxygen consumption rate of arteriolar walls was calculated based on the intra- and peri-vascular oxygen tension (PO2) values measured by phosphorescence quenching laser microscopy. The peri-vascular PO2 value of the arterioles during vasodilation was significantly higher than under control conditions, although the intravascular PO2 values under both conditions were approximately the same. On the other hand, inhibition of NO synthesis caused a significant decrease in both the intra- and peri-vascular PO2 values of the arterioles. The inhibition of NO synthesis increased the oxygen consumption rate of the vessel walls by 42%, whereas enhancement of flow-induced NO release decreased it by 34%. These results suggest that NO plays an important role not only as a regulator of peripheral vascular tone, but also as a modulator of tissue oxygen consumption by reducing oxygen consumption by vessel walls.

元の言語English
ホスト出版物のタイトルProceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08
出版者IEEE Computer Society
ページ1389-1392
ページ数4
ISBN(印刷物)9781424418152
DOI
出版物ステータスPublished - 2008 1 1
イベント30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - Vancouver, BC, Canada
継続期間: 2008 8 202008 8 25

出版物シリーズ

名前Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology"

Conference

Conference30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08
Canada
Vancouver, BC
期間08/8/2008/8/25

ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Signal Processing
  • Biomedical Engineering
  • Health Informatics

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  • これを引用

    Shibata, M., Yamakoshi, T., & Yamakoshi, K. I. (2008). Physiological role of nitric oxide in oxygen consumption by arteriolar wall. : Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 (pp. 1389-1392). [4649424] (Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology"). IEEE Computer Society. https://doi.org/10.1109/iembs.2008.4649424