抄録
The increase in the number of patients with mental disorders with depressive symptoms has become a significant problem. To prevent people developing those disorders and help with the effective recovery, it is important to quantitatively and objectively monitor an individual's mental state. Previous studies have shown the relationship between negative or depressive mood state and human prefrontal cortex (PFC) activation during verbal and spatial working memory tasks based on a near-infrared spectroscopy imaging technique. In this study, we aimed to explore a biomarker of the mental state of people in remission of mental disorders with depressive symptoms using this technique. We obtained the PFC activation of return-to-work (RTW) trainees in remission of those disorders, compared that of healthy controls, and obtained subjective questionnaire scores with the Profile of Mood States. We compared the PFC activation with the questionnaire scores by receiver operating characteristic analysis using a logistic-regression model. The results showed that the PFC activation indicates a healthy state compared to that of the RTW trainees evaluated by area-under-curve analysis. This study demonstrates that our PFC measurement technique will be useful as a quantitative and objective assessment of mental state.
本文言語 | English |
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論文番号 | 056008 |
ジャーナル | Journal of biomedical optics |
巻 | 24 |
号 | 5 |
DOI | |
出版ステータス | Published - 2019 5月 1 |
外部発表 | はい |
ASJC Scopus subject areas
- 電子材料、光学材料、および磁性材料
- 生体材料
- 原子分子物理学および光学
- 生体医工学